Research in the HGG lab focuses on the genetics and genomics of medicinal herbs. Projects related to molecular identification, population genetics and genomics, the structure, function, and expression of genomes, comparative genomics and phylogenomics, metabolomics, epigenomics and environmental genomic interactions of diverse medicinal taxa are carried out.

中药多组学实验室/中药品质多组学研究团队聚集中药资源遗传评价与应用。在基础研究方面，团队研究内容包括中药资源的分子鉴定与品质评价、中药资源分子育种、中药资源道地性的分子生态机制、次生代谢产物生物合成基因挖掘与调控网络通；在应用基础研究方面，团队推动药用类群核心种质资源库构建和新品种选育，促进中药药效成分物质基础研究与药妆产品开发与应用。

Molecular identification and quality evaluation of medicinal taxa / 中药资源分子鉴定与品质评价

In addition to the traditional morphological, physiological and biochemical identification of medicinal taxa, work in our lab includes developing diverse genetic markers (e.g., SNPs, SSRs, SVs) for their molecular identification. In particular, markers derived from different omics data are becoming increasingly powerful tools for the identification of complex taxa.

在传统形态和生理生化等资源鉴定方法的基础上，实验室致力于基于多组学数据的新型分子标记开发与应用，促进困难中药资源类群的分子精确识别，保障临床用药安全。

Core collection construction and molecular breeding of medicinal plants / 中药资源核心种质库构建和分子育种

On the basis of multi-omics data, we are developing markers for marker-assisted breeding of medicinal herbs. We have extensively sampled and preserved thousands of both wild and cultivated individuals of different medicinal taxa, and are currently constructing core collections of these taxa for both breeding and medicinal applications.

基于现代分子标记技术，开展多类群群体样本的遗传多样性评价和主要特征代谢产物多样性分析，并以此为基础构建核心种质资源库，筛选药用类群的核心种质，开展中药材新品种的人工选育研究，推动新品种审定和推广应用。

The molecular interaction between genetics and environment of medicinal plants / 中药资源道地性的分子生态机制

We used both Chrysanthemum and Coptis as models to investigate the ecological and genetic roles involved in the production of locally specific secondary metabolites in medicinal plants.

In traditional Chinese medicine, both the flowers of chrysanthemums and the rhizome of Coptis are widely used. However, the origin and evolution of the diversity involved in both the morphology and phytochemistry of these two groups of plants are far from well understood. In particular, the “Daodi” (geo-herbalism) characteristics of these plants are poorly studied, leaving the main problems in relation to the development of cultivars and their suitable planting areas.

诸药所生，皆有境界。药用类群相关于特定的生态环境产生特异的次生代谢产物供自身及人类所用，即药材道地性的重要内容。利用现代多组学的研究技术方法，实验室致力于探讨特异次生代谢产物相关于生态环境的分子遗传机制，促进对药用类群道地性的理解。

Genes involved in the biosynthetic pathways of plant metabolites / 植物次生代谢产物生物合成基因研究

Combined multi-omics data from genomics, transcriptomics and metabolomics were used to investigate the genes involved in the related biosynthetic pathway. In our lab, we have successfully constructed the CRISPR/Cas9 genome editing system. In particular, we developed a new cloning strategy to generate paired-sgRNA/Cas9 vectors containing four sgRNAs targeting the genes. This is important for the related functional research on genes. Currently, both Chrysanthemum and Coptis plants were used as models for biosynthetic genes analysis, and we have already sequenced and assembled the genome of Chrysanthemum indicum, C. nankingense, and Coptis chinensis.

基于多组学数据，开展次生代谢产物合成通路关键功能基因和调控元件的挖掘，促进对多样化终端产物形成机制的理解，推动重要次生代谢产物合成生物学的研究与应用。

Ingredient research and product development of traditional Chinese medicine / 中药药效成分物质基础研究与产品开发

Based on the region-specific resources of traditional Chinese medicinal materials, we carry out the separation, quality and efficacy evaluation of functional secondary metabolites, and promote the development and application of related products such as traditional Chinese medicine health products and traditional Chinese medicine cosmetics.

基于区域特异性中药材资源，开展功能性次生代谢物质的分离和品质与功效评价，推动中药大健康产品、中药妆品等相关的产品开发和应用。

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